The U.S.S. Ohio was designed by Henry Eckford and launched on May 30, 1820 and then immediately laid up. In 1838, she became the flagship of Commodore Isaac Hull and the U.S.S. Ohio departed New York on December 6, 1838 under the command of Captain Joseph Smith. She made passage through rough seas to Gibraltar in just 21 days with an average speed of 12 knots. After her mission to the Mediterranean she returned to Boston in 1841 and was decommissioned. In December 1846, the U.S.S. Ohio was re-commissioned under the command of Captain Silas H. Stringham and then had an extended tour in the waters in and around South America. She returned to the Boston Navy Yard on April 25, 1849 and was decommissioned on May 3, 1850. U.S.S. Ohio was sold several times before being towed to Peconic Bay, Long Island, New York where she was broken up circa 1875.