FLEMING, Alexander (1881-1995). "On the Antibacterial Action of Cultures of a Penicillium, with special Reference to their Use in the Isolation of B. Influenzae", in: The British Journal of Experimental Pathology, volume X, no. 3, pp. 226-236. [1929]. 4° (234 x 180mm). 4 illustrations, pp. 226-236 (each leaf with long severe tear, laminated). Pp. 226-236 only, disbound.

FLEMING, Alexander (1881-1995). "On the Antibacterial Action of Cultures of a Penicillium, with special Reference to their Use in the Isolation of B. Influenzae", in: The British Journal of Experimental Pathology, volume X, no. 3, pp. 226-236. [1929]. 4° (234 x 180mm). 4 illustrations, pp. 226-236 (each leaf with long severe tear, laminated). Pp. 226-236 only, disbound.

FIRST PUBLICATION OF THE SCIENTIFIC PAPER DESCRIBING THE DISCOVERY OF PENICILLIN. Fleming maintained that ideal therapeutic anti-bacterial agents should arrest the growth of bacterial invaders without affecting host tissues as ordinary germicides did. 'Sharp observation, pertinacious curiosity, and a prepared mind' enabled him to discover two outstandingly important antibacterial substances, lysozyme and afterwards penicillin. In 1928 he first observed the antibacterial effect of penicillium mold, and reported in the above paper that 'penicillin' did not interfere with leucocytic function, was nontoxic to laboratory animals, and 'may be an efficient antiseptic for application to, or injection into, areas infected with penicillin-sensitive microbes.' The first clinical trials were abandoned due to difficulties in growing the culture in a controlled way. Garrison & Morton 1933; Norman 798; PMM 420.

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