MITCHELL, John Kearsley (1793-1858). On the Cryptogamous Origin of Malarious and Epidemic Fevers. Philadelphia: Lea and Blanchard, 1849.

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MITCHELL, John Kearsley (1793-1858). On the Cryptogamous Origin of Malarious and Epidemic Fevers. Philadelphia: Lea and Blanchard, 1849.

12o (199 x 119 mm). (Some scattered foxing.) Original dark brown cloth, front cover gilt-lettered (rebacked, preserving original spine). Provenance: William Henry Welch (1850-1934), American pathologist (presentation inscription from the author's son, Silas Weir Mitchell [see lots 1204-1205], on the front flyleaves: "'An amazing book-read in the light of our own day'- My dear Welch I have but two copies of this book & you may measure my regard for you by the fact that I give you one yr. friend Weir Mitchell").

FIRST EDITION. PRESENTATION COPY FROM THE AUTHOR'S SON, SILAS WEIR MITCHELL TO WILLIAM HENRY WELCH. Although the idea that malaria might be a parasitical infection had bee suggested as early as 1844 by Hensinger, "Mitchell was the first to approach this theory in a scientific spirit" (Garrison-Morton). A FINE ASSOCIATION COPY. Garrison-Morton 5234; Heirs of Hippocrates 1594; Norman 1518.