Lot 197
197
Three offprints from The Lancet regarding pencillin from 1940, 1941 and 1943,
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Three offprints from The Lancet regarding pencillin from 1940, 1941 and 1943,

Details
Three offprints from The Lancet regarding pencillin from 1940, 1941 and 1943,
comprising:
1) CHAIN, E., FLOREY, H.W., GARDNER, A.D., HEATLEY, N.G., JENNINGS, M.A., ORR-EWING, J. and SANDERS, A.G. Penicillin as a Chemotherapeutic Agent. London: The Lancet Office, 1940. 8vo. Original printed wrappers. RARE OFFPRINT EDITION, reprinted from The Lancet (24 August 1940);
2) ABRAHAM, E.P., CHAIN, E., FLETCHER, C.M., FLOREY, C.M., GARDNER, A.D., HEATLEY, N.G. and JENNINGS, M.A. Further Observations on Penicillin. London: The Lancet Office, 1941. 8vo. Original printed wrappers. RARE OFFPRINT EDITION reprinted from The Lancet (16 August 1941);
3) and FLOREY, M.E. and H.W. FLOREY. General and Local Adminstration of Penicillin. London: The Lancet Office, 1943. 8vo. Half-tone illustrations. Original printed wrappers. RARE OFFPRINT EDITION, reprinted from The Lancet (27 March 1943).

See Illustration (3)
Literature
For 1) see: J.Carter and P.H.Muir. Printing and the Mind of Man. London and New York: 1967. 2nd Edition, No. 420b; D.H.Hook and J.M.Norman. The Haskell F.Norman Library of Science & Medicine. San Francisco: 1991. 2 vols, No. 437; and see J.M.Norman (ed.). Morton's Medical Bibliography. Aldershot and Vermont: 1991. 5th edition, No.1934;
For 2): see J.M.Norman (ed.). Morton's Medical Bibliography. Aldershot and Vermont: 1991. 5th edition, No.1934.1
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Lot Essay

In Penicillin as a Chemotherapeutic Agent the Oxford team succinctly reported their first clinical tests of penicillin carried out on mice. Further Observations on Penicillin discusses in greater detail how the Oxford team manufactured penicillin in large-scale and reports on the first clinical tests of penicillin on humans, resulting in the conclusion:"..that penicillin combines to a striking degree two most desirable qualities of a chemotherapeutic agent - low toxicity to tissue cells and powerful bacteriostatic action"(Page 32). The paper General and Local Administration of Penicillin, further explores the effectiveness of penicillin, both generally and locally, in human trials.

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