Weber was the original describer of Osler-Rendu-Weber's Hereditary Haemorrhagic Telangectasia, Sturge-Weber Disease, Weber-Christian Disease and others. The Oxford Companion notes that: "He was a supreme collector and describer of medical rarities ... In his life of close on 100 years, he saw much and forgot little; his millenary of papers seem little more than the gleanings of his vast store of knowledge."