Queen Anne (1665-1714) was the last Stuart monarch. She was the second daughter of James, Duke of York (1633-1701) subsequently James II and VII, and his first wife, Anne, Duchess of York (1637-1671). In 1683, Anne married Prince George of Denmark (1653-1708), and in 1702, on the death of her sister Mary's husband, William III, Anne became Queen. Queen Anne suffered seventeen pregnancies and lost seventeen children (including twins). Her only living child, William, Duke of Gloucester, was born on 24 July 1689 and died from smallpox, aged 11, on 30 July 1700. Anne's health declined severely durng the 1690s, but she remained committed to her duties as Queen. It was during her reign, on 1 May 1707, under the Act of Union, that England and Scotland were united as a single sovereign state, the Kingdom of Great Britain. She was succeeded by the first Hanoverian king, George I (1660-1727).