Nature, volume 171, no.4356, pp.737-741. London: Macmillan & Co., Limited, 1953." />
London, South Kensington
23 April 2008
CRICK, Francis Harry Compton (1916-2004) and James Dewey WATSON (b. 1928). "Molecular structure of nucleic acids", in: Nature, volume 171, no.4356, pp.737-741. London: Macmillan & Co., Limited, 1953.
CRICK and WATSON. "Genetical implications of the structure of deoxyribonucleic acid," in: Nature, volume 171, no.4361, pp.964-967. London: Macmillan & Co., Limited, 1953.
2 issues, 8° (247 x 174mm). Without original wrappers, in half morocco box.
SIGNED BY CRICK AND WATSON, THE FIRST ANNOUNCEMENT OF THE DISCOVERY OF DNA, THE SINGLE MOST IMPORTANT WORK IN THE HISTORY OF THE LIFE SCIENCES. Their paper, with its memorable opening 'We wish to suggest a stucture for the salt of deoxrybose nucleic acid (D.N.A.). This structure has novel features which are of considerable biological interest', correctly interpreted the crystalline structure of D.N.A. This discovery explained how heredity messages could be encoded in a crystalline structure that was stable in the latter sense and yet allowed for both replication and mutation. Towards the end of the first paper, Watson and Crick write that 'it has not escaped our notice that the specific pairing we have postulated immediately suggests a possible copying mechanism for the genetic material'. The publication of their joint paper in nature revolutionised biochemistry and the other life sciences, and profoundly affected the study of molecular biology. Garrison-Morton 256.3. (2)
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