VIRCHOW, Rudolf (1821-1902). Die Cellularpathologie in ihrer Begründing auf physiologische und pathologische Gewebelehre. Berlin: August Hirschwald, 1858. 8° (222 x 138 mm). Half-title, title with copyright on verso, 144 wood engravings in the text, of which one full-page and several white-on-black. 28pp. of publisher's catalogue at end (a little show-through from the woodcuts, top margins very lightly browned). Original cloth-backed printed boards (rubbed, corners worn). Provenance: PRESENTATION COPY, INSCRIBED BY THE AUTHOR to Herrn Geh. Rath Mitscherlich, famous German pharmacologist (inscription at head of front board) -- Hermann Coenen, professor of surgery in Breslau and student of Virchow (signature in black ink on title, Breslau, 1911) -- H. Hellner, 1945 (signature in blue ink on title).
FIRST EDITION OF THE FOUNDATION WORK OF CELLULAR PATHOLOGY AND 'ONE OF THE MOST IMPORTANT BOOKS IN THE HISTORY OF MEDICINE', (Garrison-Morton). In this work, an almost verbatim transcription of a series of 20 lectures delivered at the new Pathological Institute in Berlin in February-April 1858, Virchow set forth the now universally accepted concept of disease as a state of conflict between healthy and diseased cells. Virchow's research into the function, structure and development of cells was made possible by technical improvements in the microscope and in biochemical techniques. 'For Virchow the microscope became the central tool for reducing pathological processes to alterations occurring at the cellular level. Hence, the cell became the fundamental living unit in both health and disease--a biological rather than a mechanical entity. Virchow's notion of cellular pathology implied that all the manifestations of disease could be reduced to disturbances of living cells. Moreover, according to Virchow's famous principle, 'omnis cellula e cellula,' all cells originated from other cells. Cellular function, in turn, depended on intracellular physiochemical changes which were reflected in the varying morphology' (DSB). 'Every morbid structure therefore consists of cells, which, according to this axiom themselves come from pre-existing cells. The seat of any disease must therefore be in the cell. On this basis, Virchow analysed disease and diseased tissue and proposed the idea that disease is a conflict between healthy and morbid cells. This was the beginning of modern pathology...' (Grolier Medicine). COPIES IN THE ORIGINAL CLOTH-BACKED BOARDS ARE RARE. Dibner Heralds of Science 132; Garrison-Morton 2299; Grolier/Horblit 99; Grolier Medicine 69; Heirs of Hippocrates 1892;