17 June 2008
VIRCHOW, Rudolf (1821-1902). Die Cellularpathologie in ihrer Begründung auf physiologische und pathologische Gewebelehre. Berlin: August Hirschwald, 1858.
8o (218 x 135 mm). Half-title. 144 wood engravings in the text, of which one full-page and several white-on-black. (Some minor marginal browning or staining.) Original quarter cloth and marbled boards (upper joint repaired, some wear to edges and rubbing to sides); folding case. Provenance: Prof. Dr. Schwartz (bookplate and ink stamp).
FIRST EDITION OF THE FOUNDATION WORK OF CELLULAR PATHOLOGY AND "ONE OF THE MOST IMPORTANT BOOKS IN THE HISTORY OF MEDICINE" (Garrison-Morton). In this work, an almost verbatim transcription of a series of 20 lectures delivered at the new Pathological Institute in Berlin in February-April 1858, Virchow set forth the now universally accepted concept of disease as a state of conflict between healthy and diseased cells. Virchow's research into the function, structure and development of cells was made possible by technical improvements in the microscope and in biochemical techniques. "For Virchow the microscope became the central tool for reducing pathological processes to alterations occurring at the cellular level. Hence, the cell became the fundamental living unit in both health and disease--a biological rather than a mechanical entity. Virchow's notion of cellular pathology implied that all the manifestations of disease could be reduced to disturbances of living cells. Moreover, according to Virchow's famous principle, 'omnis cellula e cellula,' all cells originated from other cells. Cellular function, in turn, depended on intracellular physiochemical changes which were reflected in the varying morphology" (DSB). "Every morbid structure therefore consists of cells, which, according to this axiom themselves come from pre-existing cells. The seat of any disease must therefore be in the cell. On this basis, Virchow analysed disease and diseased tissue and proposed the idea that disease is a conflict between healthy and morbid cells. This was the beginning of modern pathology..." (Grolier Medicine). Dibner, Heralds of Science 132; Garrison-Morton 2299; Grolier/Horblit 99; Grolier Medicine 69; Heirs of Hippocrates 1892; Norman 2156; Osler 1624; PMM 307c; Waller 9996.
Contact Client Service
New York +1 212 636 2000
London +44 (0)20 7839 9060
Asia +852 2760 1766
The Plantin Polyglot bible — offered in London on 11 July — makes an emotional homecoming to the Antwerp printing press where it was produced some 450 years ago
As Christie’s offers 178 works from his personal collection, the illustrator of Charlie and the Chocolate Factory offers us a glimpse of his creative process
Mark Wiltshire, Associate Specialist in Science & Books, walks us through the history of Christianity’s most influential printed text
Seven expert tips on collecting, whether you seek affordable works on paper or a museum-quality masterpiece
The artistic director of The Grange Festival — a month-long staging of opera in the south of England — selects favourite works from Christie’s Classic Week in London