Catherine Clifford was the eldest daughter of Henry de Clifford, 1st Earl of Cumberland, and his second wife Margaret, daughter of Henry Percy, 5th Earl of Northumberland.
Catherine first married John, 8th Baron Scrope of Bolton, in about 1530. Lord Scrope was summoned to Parliament from 5th January 1533 to 5th January 1547 and was involved in the uprising of 1536/7 known as the 'Pilgrimage of Grace', led by Robert Aske. Catherine had five sons and four daughters by Lord Scrope. The eldest of these sons, Henry, succeeded to the title when Lord Scrope died in June 1549. Catherine went on to have four more sons and another daughter by her second husband, Sir Richard Cholmley. She died in 1598 and was buried at Whitby.