It is very unusual to depict nuns in thangkas. The two in this thangka are likely members of the important Khon family, consisting of the descendants of Sakya Pandita and Chogyal Phagpa. In the Khon family there were many famous nuns who were considered equal to the men and given the most important teachings and instructions from the Hevajra, Chakrasamvara, Vajrajogini, Kalachakra Tantras. In the 19th century, the most famous of these nuns was Jetsunma Tamdrin Wangmo, who traveled extensively across Tibet and was a teacher to many great lamas of all the schools. Today, the sister of Sakya Trizin (the highest lama in the Sakya school) also teaches the highest forms of tantric practice. Her title and name are Jetsunma Chimey Drolkar of the Drolma Palace of the Khon family of Sakya.