Formerly thought to be the son of Niccolò di Pietro Gerini, Lorenzo di Niccolò was in fact only his assistant. He collaborated with Gerini in the last years of the fourteenth century on works such as the frescoes in the Chapter House of the church of San Francesco at Prato and the Coronation of the Virgin polyptych for the church of Santa Felicità in Florence, now in the Accademia there. He subsequently undertook a number of significant commissions on his own, including altarpieces in the Museo Comunale at San Gimignano (1401, signed), in the church of San Domenico at Cortona (1402), in the Cini Collection in Venice (1404) and in the parish church of San Lorenzo in Collina (1412).