Related to the fresco painted by Morazzone in one of the compartments of the cupola of the Duomo at Piacenza, M. Gregori, Catalogo della Mostra del Morazzone, exhib. cat., Milan, 1962, no. 85, fig. 223. The commission required the artist to decorate the eight compartments of the cupola with Old Testament Prophets. The frescoes were begun, according to Baglione, in 1625 but was interupted early in 1626 when the artist died suddenly. Morazzone had by then only completed two of the compartments. On 12 May 1626 Guercino took up the task and painted the six remaining compartments.
Morazzone's study for the Prophet Isaiah is bound, along with a number of his other drawings, in the Codice Bonola in Warsaw, M. Gregori, op. cit., fig. 224.